Wow6432 is a Windows registry entry and has nothing to do with the game WoW.
Wow6432 means you’re running a 64-bit version of Windows and allows to manage 32-bit applications that runs on a 64-bit version of Windows. This entry is localized here:
When the 32-bit app performs a registry query on HKEY_LOCAL_MACHINE\SOFTWARE\<company>\<product>, Windows automatically redirects the query to HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\<company>\<product>
There’s no need to take into account Wow6432 during the development of a 32-bit application. The management of Wow6432 is totally transparent for the developer. Kombustor, for example, modifies Afterburner registry entry:
HKEY_LOCAL_MACHINE\SOFTWARE\MSI\Afterburner. During the dev of Kombustor, I never made a reference to Wow6432.